UVAS Library

Your cart is empty.

Your search returned 2 results. Subscribe to this search

Not what you expected? Check for suggestions
Unhighlight Highlight
|
1.
No cover image available
Effect Of Total Particulate Matter From Commercial Cigrettes On Wound Healing In Mice

by Sidra Abdil Rahman | Prof.Dr.Muhammad Ashraf | Dr.Sheryar Afzal | Prof.Dr.Zafar Iqbal Ch.

Material type: book Book; Format: print ; Literary form: not fiction Publisher: 2009Dissertation note: ACigarette smoking is considered as the most important cause of death in developed countries. Wound healing in the skin is a multifarious orchestration of cellular processes and cigarette smoking may grounds for delayed wound healing. The aim of this study was to investigate, the plausible association between exposures of cigarette total particulate matter (TPM) on wound healing. The invivo mice model of wound healing was customized for determinenation of assorted events of wound healing. A total of 49 adult mice separated in seven groups and kept under standard conditions of ventilation and temperature. Four brands of commercially available cigarette were selected for the current study. All the treated animals were exposed to TPM ointment for 12 days. A highly considerable diminution in wound closure was pragmatic among all TPM treated groups from day 6 to day 8 post-wounding. Histological investigations unveiled a noteworthy impede in the outcome of re-epithelialization, dermal matrix regeneration and maturation of collagen bundles among all TPM-exposed wounds. Delayed commencement of neovascularization was pragmatic among TPM treated groups, at day 12 post wounding. Quantification was done with the help of scan probing image processing software and image processing system. Abbot curve, angular spectrum and different other parameters of 3D surface behavior of wounds revealed a very highly significant reduction in angiogenesis at day 6 and day 8 post-wounding, which points that application of TPM instigate extensive delay in trigging the progression of angiogenesis, resulting delayed onset of wound healing. These annotations validate the damaging effects of TPM on the healing of wounds and excessive use of TPM may lead to the production of chronic wounds and oral ulcers. Availability: Items available for loan: UVAS Library [Call number: 1071,T] (1).

Place hold Add to cart
2.
No cover image available
Effect Of Two-Stroke Auto Rickshaw Smoke Solution On Wound Healing In Mice

by Aqeela Iqbal | Prof.Dr.Muhammad Ashraf | Dr.Muhammad Ovais Omer | Prof.Dr.Zafar.

Material type: book Book; Format: print Publisher: 2009Dissertation note: The use of 3-wheel auto-rickshaws powered by a 2-stroke engine is widespread in south Asia; exhaust from these vehicles may cause different types of toxicities resulting in different pathologies. The aim of this study was to explore the association between exposure to 2-stroke auto-rickshaw smoke solution (2SARSS) and wound healing. The in vivo model of wound healing was customized to evaluate different stages of wound healing. A total of 56 mice were used of aged 4-5 weeks. After anesthetizing and hair removing from dorsum side of mice a wound of 3mm diameter was generated with the help of a sterile wound puncture. Smoke was collected in the lOOml distilled water from six 2-stroke rickshaws and then these solutions were filtered by syringe filters. 10% ointment of all the samples was prepared in Petroleum Jelly and applied to the experimental group, petroleum jelly to positive control group, no treatment was applied to negative control. Macroscopic evaluation was done by using high resolution camera photographs and measurement of wound by vernier caliper on alternate days. At the end of the study (day 12) histological evaluation was done when the control group wounds were healed. Histological examination revealed a significant delay in the outcome of re-epithelialization, dermal matrix regeneration, and maturation of collagen bundles among all 2SARSS-exposed wounds. Delayed activation of neovascularization was seen in the 2SARSS-treated groups at day 12 post-wounding. The Abbot curve, angular spectrum, and several other 3D surface parameters of reverse wound topographies revealed a highly significant reduction (p<O.OOl) in angiogenesis. These results demonstrate that application of 2SARSS causes a substantial delay in the progression of angiogenesis, resulting in delayed onset of wound healing. These observations validate the damaging effects of 2SARSS on wound healing. Thus, people who are directly or indirectly exposed to this toxic exhaust are expected to have delayed wound healing, which could result in chronic wounds. Availability: Items available for loan: UVAS Library [Call number: 1083,T] (1).

Place hold Add to cart

Implemented and Maintained by UVAS Library.
For any Suggestions/Query Contact to library or Email:rehana.kousar@uvas.edu.pk Phone:+91 99239068
Website/OPAC best viewed in Mozilla Browser in 1366X768 Resolution.